NAD and NMN as anti-aging health products
Dr. Niveditha Navin
In June 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time, they added aging. The classification of aging paves the way for new research into novel therapeutics to delay age related disorders and diseases.
Elderly population has been progressively rising in the world, thus the demand for anti-aging health products to assure longevity, as well as to ameliorate age-related complications, is also on the rise.
Age affects you on a Cellular Level
As we age, our cells undergo multiple chemical processes of aging leading to release of unstable and harmful substances that negatively affects your mitochondria, proteins, and DNA, subsequently putting cell regeneration to a halt. If your body can no longer produce new, healthy cells to maintain various functions; aging and eventual death occurs.
This is where anti-aging compounds work by restoring DNA and promoting regeneration, producing antioxidant and anti-glycation effects. Among various anti-aging compounds, one of the most effective compound that has been gaining consumer attention is the Nicotinamide adenine dinucleotide (NAD+).
By middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have shown that across the kingdom of life, an increase in NAD+ triggers shifts that enhances survival, including boosting energy production and upregulating cellular repair.
What does NAD+ do?
The NAD story took off towards the end of 2013 with a high-profile paper by Harvard's scientist, David Sinclair and colleagues. NAD+, found in all our cells, is a molecule that supports cell function in a number of important ways, including keeping our DNA healthy, converting food into usable energy and regulating our sleep/wake cycles. Low NAD levels are associated with the increased risk of Heart disease, Type 2 diabetes, Alzheimer’s disease and accelerated aging. But there is more to NAD+ than this. NAD+ can activate the anti-aging proteins such as SIRT to keep mitochondria running smoothly by preventing cell deterioration. However, the question is how much of the NAD+ does our body absorb in an oral form? The answer is probably not much and that's where NMN comes in. NMN, a natural precursor of NAD+ meaning it becomes NAD+ in our body after taken orally, is a stable and reliable NAD+ activator that naturally boosts the body’s NAD+ levels.
Here are a few benefits of NMN- Promotes cellular rejuvenation
- Enhances endurance and fights fatigue
- Promotes muscle recovery
- Helps with DNA repair
- Enhances cognitive function
- NMN can lower levels of inflammation
- Improves your metabolism
- Youthful looking skin
Apart from all these benefits, several clinical studies have also proven the safety of NMN in humans. This means you get to enjoy a long healthier life without any harmful effects.
About Dr. Niveditha Navin
Dr. Navin is a clinical research specialist, who holds a degree in dentistry. After completing her postgraduate diploma in clinical research, she has experience working as a clinical affairs specialist in the pharmaceutical industry. She is passionate about medicine and wishes to carve a distinct niche in the field of research.
- Zhavoronkov A, et al. Classifying aging as a disease in the context of ICD-11. Front Genet. 2015. November 4;6:326.
- Schultz MB, et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab. 2016. June 14; 23(6): 965–966